10^th World Congress on Alzheimers Disease & Dementia May 30-31, 2018 Osaka, Japan

Biography:

Jae-Kyung Lee has completed her PhD in UNT Health Science Center and Postdoctoral studies from UT Southwestern Medical Center at Dallas. She had worked as an Assiatant Professor at Emory University until 2015. Currently, she is an Assistant Professor in University of Georgia, USA. She has published more than 24 papers in reputed journals. Her research focused on understanding how inflammation influences neurodegenerative diseases.

Abstract:

Insulin resistance and aging-related metabolic disorders constitute serious threats to human health as risk factors for Alzheimer’s Disease (AD); especially impaired brain glucose homeostasis was related to the severity of the AD pathology. Regulator of G-protein Signaling proteins (RGSs) are a family of proteins that negatively regulate G-Protein Coupled Receptors (GPCR) through their GTPase Accelerating Protein (GAP) activity. RGS10 is one of the smallest RGS family proteins which we have shown to negatively regulate microglia activation and the level of RGS10 in microglia significantly decreased within the microglia by age. RGS10-deficient microglia displayed impaired phagocytic activity to amyloid-beta fibrils (fAb). Interestingly, RGS10-deficient mice spontaneously gained weight with age (>15 months) and the level of RGS10 protein was decreased in postmortem brains of the AD and Frontal Temporal Dementia (FTD). Our data demonstrate that RGS10-deficient mice display impaired glucose tolerance, the high level of triglycerides (TG) in plasma. RGS10-deficient mice spontaneously gained weight with age (>15 months). We also tested whether RGS10 plays a role in high-fat-induced chronic inflammation and glucose metabolism as a risk factor for metabolic disorder in the periphery and the CNS. Indeed, HFD-fed RGS10-deficient mice gained significantly more weight compared to HFD-fed wild-type (WT) mice. Importantly, HFD-fed RGS10-deficient mice displayed an insulin resistance phenotype and impaired Long-Term Potentiation (LTP). These data implicate RGS10 may play a critical role of in insulin sensitivity during metabolic disorders in the periphery and the CNS. Importantly, peripheral metabolic disorders, including obesity and insulin resistance along with chronic inflammation have been shown to contribute to development and progression of cognitive impairment and Alzheimer’s disease through multiple mechanisms. Our data strongly implicate the role of RGS10 in modulating metabolic homeostatsis related to its role in neuroinflammation. Elucidating RGS10 function in maintaining metabolic homeostasis in the CNS and periphery may provide the mechanism to link aging associated chronic inflammation and metabolic disorders, which could be a potential therapeutic target for Alzheimer’s diseases with dual effects on both inflammation and metabolic disruption. Overall, our study produced highly novel data delineating potential mechanisms of RGS10 function in metabolic homeostasis in the brain.

Biography:

Jun-Ah Song has completed her PhD from University of Michigan, School of Nursing and Postdoctoral studies from Oregon Health and Sciences University. She is a Professor of Korea University College of Nursing and an Expert Committee of the National Institute of Dementia in Korea. She has been serving as a Chief Editor of the Journal of Korean Gerontological Nursing and an Editorial Board Member of other professional journals. She has published more than 30 papers about caregiving issues related to dementia in reputed national and international journals.

Abstract:

It is important for health professionals to teach family caregivers of persons with dementia about how to deal with Behavioral Psychological Symptoms of Dementia (BPSD) well. However, little information is available about what aspects exactly they need to learn to be competent in managing BPSD. The purpose of this study was to explore attributes of the concept of family caregiver’s competence for managing BPSD (CM-BPSD). A rapid realist review was conducted to synthesize the complex range of concepts and define attributes of the family caregiver’s CM-BPSD from the comprehensive literature. Three databases were used including MEDLINE, Embase and CINAHL. The search terms used were dementia, caregiver, coping (managing) and competence. The selection criteria were articles being published in English between 1990 and 2017 and considered appropriate for the topic. Among the 235 articles, 89 were excluded for duplication and six for not being written in English. From the concept synthesis of competence for managing, four dimensions were defined: Judging, setting the direction, adjusting and reflecting. For the concept of family caregiver’s CM-BPSD, eleven attributes were derived. Findings of this study suggest that the concept of family caregiver’s CM-BPSD should reflect the procedural aspect. Reflecting can be considered as a meta-competence because it may influence the other three phases of managing BPSD. A field study would be of great value to clarify the attributes of the concept.

Biography:

Hyunji Jo has graduated from Konyang University in 2016. She is currently pursuing Doctoral studies in Pharmacy at Ewha Womans University. Her research focuses on studying the role of AMPK as a novel therapeutic target for Alzheimer’s disease.

Abstract:

Alzheimer’s Disease (AD) is an aging-associated neurodegenerative disease. AD patients suffer from behavioral deficits, mental distress and progressive memory impairments. Currently existing AD drugs are merely symptomatic treatments. Therefore, we need to find a novel therapeutic strategy for AD. Amyloid beta (Aβ), known as a marker of AD, is generated by cleaving Amyloid-Precursor Protein (APP) with β-secretase (BACE1) and γ-secretase. Identifying effective methods to suppress the Aβ accumulation has long been of great interest. Recently, AMP-Activated Protein Kinase (AMPK), a serine/threonine protein kinase, began to be focused as a novel therapeutic target since it has been reported to regulate formation of Aβ. Thus, in this study, 100 compounds were selected from screening a chemical library containing one million compounds by in silico study. We finally found YE-06 through chemical modifications and various bioassays. In accordance with the docking study, YE-06 potentially bound to the AMP binding site of AMPK. Compared to Metformin, which is a well-known AMPK activator, YE-06 significantly activated AMPK and consequently down-regulated the protein level of BACE1. The mRNA level of BACE1 was significantly reduced. We showed improvements in the cognition and movement coordination of AD rat model in YE-06 treated group through water maze test, probe test, passive avoidance test, rotarod test and vertical pole test. YE-06 efficiently increased ACh and decreased the AChE activity. Also, YE-06 significantly reduced neuronal cell death of AD rat models. Therefore, our results suggest that YE-06 is a potential compound for AD treatment.

Biography:

Yung-Chih Kuo is a Professor at National Chung Cheng University, Taiwan. His research interests are focused on biomaterials, nanomedicine, tissue engineering, blood-brain barrier, cancer therapy, nerve regeneration, spinal cord injury and stroke treatment and Alzheimer’s and Parkinson’s disease therapy. He has authored over 140 SCI journal papers. He is a Fellow of Royal Society of Chemistry, UK and an Honor Member of Phi Tau Phi Society. He has also won Prof. Yen-Ping Shih Award in 2017; Best Paper Award in 2016 and 2008; Prof. Tsai-Teh Lai Award in 2015; Special and Talented Scholar Award in 2013 and Outstanding Research Award in 2013.

Abstract:

Polymeric nanoparticles (NPs) combined with lipids can have profound effects on treatment efficacy in patients with neurological disorders such as Alzheimer’s Disease (AD). We developed polyacrylamide (PAAM)-cardiolipin (CL)-poly(lactide-co-glycolide) (PLGA) NPs grafted with surface 83-14 Monoclonal Antibody (MAb) to carry Rosmarinic Acid (RA) and Curcumin (CUR). This drug delivery system was used to cross the Blood-Brain Barrier (BBB) and enhance the viability of SK-N-MC cells insulted with β-Amyloid (Aβ) deposits. Experimental evidence revealed that an increase in the concentration of 83-14 MAb enhanced the permeability coefficient of RA and CUR using the nanocarriers. The levels of phosphorylated p38 and phosphorylated τ-protein at serine 202 in degenerated SK-N-MC cells were in the order: Aβ>(Aβ+RA-CUR)>(Aβ+83-14 MAb-RA-CUR-PAAM-PLGA NPs)>(Aβ+83-14 MAb-RA-CUR-PAAM-CL-PLGA NPs)≈control. The viability of SK-N-MC cells reduced with time and CL in 83-14 MAb-RA-CUR-PAAM-CL-PLGA NPs advantaged Aβ-targeted delivery of RA-CUR. These results evidenced that the current 83-14 MAb-RA-CUR-PAAM-CL-PLGA NPs can be a promising pharmacotherapy to permeate the BBB and reduce the fibrillar Aβ-induced neurotoxicity.

Biography:

Joon Huyk Park has completed his PhD from Seoul National University, South Korea. He is an Assoicate Professor at Jeju National University, School of Medicine and the Director of Jeju Province Dementia Center. His research interests include epidemiology of dementia, BPSD and vascular depression and has published more than 50 papers in reputed journals.

Abstract:

The purpose of this study is to investigate the effects of three major neuroimaging markers of Cerebral Autosomal Dominant Arteriopathy with subcortical infarcts and Leukoencephalophathy (CADASIL) on cognition and Quality of Life (QoL). 84 participants with CADASIL completed the comprehensive clinical evaluation including 3T MRI and genotyping of NOTCH3. WMH volume was calculated using volumes were measure by a fully automated monospectral segmentation method using FLAIR MRIs. Neurocognitive function was evaluated using CERAD-K neuropsychological assessment battery (CERAD-NP) and quality of life was measured using the Short Form 36 Health Survey Questionnaire (SF-36). Greater WMH volume had a negative impact on 8 neurocognitive tests (p<0.05; t-test) in CERAD-NP except constructional praxis. The number of lacunar infarctions was associated with poor performance of MMSE-KC (p<0.05; t-test) only and the number of CMBs was not related to any neurocognitive test scores. WMH volume was negatively associated with Physical Function (PF), role limitations, Vitality (VT), Mental Health (MH), Physical Component Score (PCS) and the mental component score. The number of lacunar infarction was only related to poor PF (p<0.05; t-test). The number of CMB was associated with the lower scores of quality of life, especially in general health, VT, MH and PCS. WMH volume [Odds Ratio (OR): 1.03; 95% Confidence Interval (CI): 1.007-1.060] in patients with CADASIL was associated with dementia, indicating that for every 1 ml of WMH volume, the risk of depressive disorder increased by 3%. WMH volume has the most significant effect on both cognitive function and quality of life.

Biography:

Dong-woo Lee has completed his MD at the age of 25 years from Seoul National University. He is working as a Professor in Deparement of Psychiatry, Inje University Sanggye Paik Hospital, Seoul, South Korea. He is also the director of Nowon Dementia Support Center.

Abstract:

Dementia is a chronic, disabling illness which is most feared by elderly people. Dementia causes heavy caregiver burden on the family. Dementia also imposes much burden on the society, making it as one of the major public health problem in many countries. Actually OECD  recommended to pose a priority to dementia management as a public health task.  As the Korean population is rapidly aging, there is a rapid increase of people with dementia in Korea. In Korea, the people with dementia doubles every 15 year, and the economic burden of care for dementia doubles every 10 years.  To cope with this rapidly increasing burden of dementia, Korean government has launched :”Plan for National Responsibility for dementia”. The plan is composed of distributing dementia reassuring center nationwide, setting up dementia reassuring hospital, and decreasing the burden of paid money for medical treatment and long-term care for dementia. The major hurdles in implementing the plan and the strategies to overcome such hurdles are suggested.

Biography:

Herman Moreno: Associate Professor of Neurology and Pharmacology/Physiology at SUNY Downstate, New York USA:  The laboratory of Moreno focuses mainly in functional analysis of mice modeling Alzheimer’s disease and other neurodegenerative diseases. The team uses, state of the art electrophysiological techniques, coupled with calcium imaging and functional MRI

Abstract:

Statement of the Problem. Alzheimer’s disease (AD) is characterized by synaptic dysfunction early in the progression of the disease. It remains unknown the specific neuronal abnormalities produced by AD related pathology (amyloid and tau) to the entorhinal cortex (EC)-hippocampus circuit, the region targeted earliest by AD. Here we address this issue by studying mice that express mutated human amyloid precursor protein (hAPP) or mutated human tau protein (hTau) or both in the EC. This approach allowed us to investigate the two pathologies separately and together Additionally we also studied mice expressing the main genetic risk factor for AD (APOE4) .Mice (APOE4) were compared to those expressing APOE3. The experiments showed that expression of mutant hAPP in EC (EC-hAPP) produced a significant increase in the duration of spontaneous extracellular field potentials in the superficial layers of both Medial EC and Lateral EC. We also observed that in EC-hAPP mice, pyramidal neurons of the subiculum, which are monosynaptically excited by EC layer III/II neurons, showed miniature excitatory postsynaptic currents having reduced amplitude, suggesting that the increased excitation observed in EC induced a compensatory negative feedback in subicular projection neurons, a process known as synaptic homeostasis. Modeling of the EC-hippocampus microcircuits indicates that EC hyperexcitability and subicular synaptic downscaling of mice expressing hAPP could be explained by EC interneuron pruning.

Biography:

Ivan Pradhana is a 4th grade medical student in the University of Indonesia. With the help from his colleagues, Ficky Huang and Edelyne Chelsea, also from his research supervisor, Martina Wiwie, he conducted this research as a requirement for getting his bachelor degree on medicine. Before this research, Ivan collaborated with other researchers and successfully published a research with the title of Correlation of Behavioral and Psychological Symptoms of Dementia and Caregivers' Physical and Mental Health in the 20th Asia Pacific Regional Conference: Alzheimer’s Disease International 2017.

Abstract:

It is estimated that 30-50% of people with dementia (PWD) suffer from significant depression. This fact indicates that for most PWD, depression occurs at the same time as cognitive decline. Research explains that this happens because PWD cannot run their daily activities independently and they (tend to) forget many essential memories, such as their family. It is also known that the risk of depression is higher for  highly educated people. This research was conducted with the intention to find the correlation between depression score and global cognitive score in 42 PWD using the Montgomery-Asberg Depression Rating Scale (MADRS) and the Mini Mental State Examination (MMSE) to assess the symptoms of depression and the global cognitive score, respectively. PWD included in this research were only those who have an MMSE score between 17 and 23 (mild cognitive impairment), and an MADRS score below 34 (no depression, mild depression, and moderate depression). Mild depression occurred in 41 out of 42 subjects (97,6%) and the global cognitive score mean was 19,53; therefore, depression score is strongly correlated to the the global cognitive score (r=0,647, p<0,001). It is assumed that many PWD are aware of their declining cognitive ability often leading to insecurities because of their condition. Some PWD experienced apathy, loss of appetite, and sleep disturbance. Because of these discoveries, it was concluded that PWD who have higher global cognitive scores also have higher depression scores.

Biography:

Dr. Ian James Martins is an Editor/Reveiwer for Open Acess Pub/MDPI journals. Appointed as the Chief Editor for International Journal of Diabetes Research (2014-2018), Research and Reviews: Neuroscience (2016-2018) and Journal of Diabetes and Clinical Studies (2017-2018). BIT Member (BIT Congress. Inc). Scientist for Science Advisory Board (USA) and Academic with Academia.edu. H-index of 43, (ResearchGate STATs (23), Mendeley STATS (20). Scientific research citations accumulated to >3300. Lifetime Membership by International Agency for Standards and Ratings as Fellow. Winner (World Academic Championship -2017) in Diabetes and Medical Science (Nutrition). Conferred with the RICHARD KUHN RESEARCH AWARD-2015 ENDOCRINOLOGY AND METABOLISM.

Abstract:

The main constituent of plaques in the brain of Alzheimer’s disease (AD) individuals namely amyloid beta (Aβ) is a proteolytic product of a larger protein the amyloid precursor protein (APP) protein. Carriers of the apo E4 allele are at greater risk of developing AD with increased deposition of amyloid beta plaques in Western countries. Protein and Aβ homeostasis is now crucial to the lifespan of organisms and is an important feature that determines the aging process in obesity, diabetes and neurodegenerative diseases. The scientific understanding of the maintenance of peripheral blood plasma Aβ and caffeine metabolism has now become essential to prevent neurodegeneration that is linked to Type 3 diabetes. The concentration of Aβ within the brain is determined by hepatic Aβ clearance and interest in the liver has increased markedly since in Western countries the incidence of non-alcoholic fatty liver disease (NAFLD) and insulin resistance has reached approx. 20% of the developed world. Induction of Type 3 diabetes is related to delayed hepatic caffeine metabolism (NAFLD) with circadian dysynchrony (Type 3 diabetes) connected to defective peripheral hepatic caffeine and Aβ metabolism. Healthy diets stabilize Type 3 diabetes and maintain the circadian rhythm with relevance to brain insulin resistance and Alzheimer’s disease.

Biography:

I had completed PhD from Seoul National University. I am an assoicate professor at Jeju National University School of Medicine and a director of Jeju Province Dementia Center. My recearch interests include epidemiology of dementia, BPSD, and vascular depression. I have published more than 50 papers in reputed journals.

Abstract:

The purpose of this study is to investigate the effects of three major neuroimaging markers of Cerebral Autosomal Dominant Arteriopathy with Subcortical infarcts and Leukoencephalophathy (CADASIL) on cognition and quality of life (QoL). Eighty four participants with CADASIL completed the comprehensive clinical evaluation including 3T MRI and genotyping of NOTCH3. WMH volume was calculated using volumes were measure by a fully automated monospectral segmentation method using FLAIR MRIs. Neurocognitive function was evaluated using CERAD-K neuropsychological assessment battery (CERAD-NP) and quality of life was measured using the Short Form 36 Health Survey Questionnaire (SF-36). Greater WMH volume had a negative impact on 8 neurocognitive tests (p<0.05, t-test) in CERAD-NP except constructional praxis. The number of lacunar infarctions was associated with poor performance of MMSE-KC (p<0.05, t-test) only, and the number of CMBs was not related to any neurocognitive test scores. WMH volume was negatively associated with physical function (PF), role limitations, vitality (VT), mental health (MH), physical component score (PCS), and the mental component score. The number of lacunar infarction was only related to poor PF (p<0.05, t-test). The number of CMB was associated with the lower scores of quality of life, especially in general health, VT, MH, and PCS. WMH volume (odds ratio [OR]: 1.03, 95% confidence interval [CI]: 1.007-1.060) in patients with CADASIL was associated with dementia, indicating that for every 1ml of WMH volume, the risk of depressive disorder increased by 3%. WMH volume has the most significant effect on both cognitive function and quality of life.

Biography:

Dr. Bruno Vincent, has completed his PhD from the University of Nice, France, in 1996. He then joined the Rockefeller University in New York as a post-doctoral fellow. Back to France in 1999 at the Institute of Molecular and Cellular Pharmacology in Sophia-Antipolis, he took the position of permanent researcher at the National Center for Scientific Research (CNRS) in 2001 and was promoted Research Director in 2011. In 2010, Dr. Vincent moved to Mahidol University in Bangkok where his research team is working on the identification of new AD-regulating factors. Dr. Vincent has published 60 articles in reputed international journals.      
 

Abstract:

Sox2 is a transcription factor that controls the balance between stem cells self-renewal and differentiation, thereby contributing to the control of neurogenesis. Importantly, Sox2 deficiency triggers neurodegeneration in the adult brain. Moreover, Sox2 co localizes with the b-amyloid precursor protein (bAPP) in stem cells and Sox2 levels are decreased in the brain of Alzheimer’s disease (AD) patients.

We have recently reported the existence of functional network engaging Sox2, the bAPP intracellular domain AICD and the a-secretase ADAM10 in vitro in human cells. Indeed, Sox2 is a potent activator of the non amyloidogenic processing of bAPP by increasing the expression of ADAM10. Secondly, transient overexpression of the pro-apoptotic C-terminal bAPP-derived AICD50 metabolite reduces Sox2 transcription whereas inhibiting AICD production with a g-secretase inhibitor augments Sox2 expression, and consequently ADAM10 protein levels, in HEK293 and SH-SY5Y cell lines. Experiments carried out in vivo indicate that Sox2 levels are diminished in the hippocampus of mouse models of AD when compared to control animals. Whether ADAM10 and Sox2 co-localize in neurogenic areas of the adult mouse brain and determining if this co localization is impaired in transgenic AD models is currently under investigation. Finally, the impact of the pharmacological or the genetic modulation of this network on the reprogramming of human induced pluripotent stem cells into neurons is currently monitored in an in vitro model of neurogenesis.

Altogether, our data suggest that enhancing the Sox2/ADAM10 axis may favor neuroprotection and neurogenesis during the development of AD.

Biography:

Lysnara Lial has completed her Master Degree in Biomedical Sciences and graduated in Physiotherapy from a well-known university in Brazil, she has dedicated the last 3 years to study and treat neurological disorders, women's healthy and skeletal/muscular diseases. During the Masters she could enrich her experience in formulating and implementation of a varied therapy programs and performing patient assessment. She has published more than 13 papers in reputed journals.

Abstract:

The clinical practice of physiotherapists includes Proprioceptive Neuromuscular Facilitation (PNF), which is a treatment concept that accelerates the response of neuromuscular mechanisms through spiral and diagonal movements. The adaptations that occur in the nervous system following PNF are still poorly described in the literature. Thus, the aim of this study was to investigate the electrophysiological changes in the fronto-parietal circuit during PNF and movement in the sagittal and diagonal patterns. This study included 30 female participants, who were divided into 3 groups (control, PNF, and flexion groups). Electroencephalogram measurements were determined before and after tasks were performed by each group. For the statistical analysis, a two-way ANOVA was performed for the factors, group, and time. Interactions between the two factors were investigated using a one-way ANOVA. P <0.004 was considered significant. The results showed an increase in alpha absolute power in the left dorsolateral prefrontal cortex and upper left parietal cortex of the PNF group, suggesting these areas work together to execute a motor action. The PNF group showed a greater alpha absolute power compared with the other groups, indicating a specific cortical demand for planning and attention, reinforcing its use for the rehabilitation of individuals.

Biography:

Kathy is a registered nurse with 14 years’ experience in the acute hospital setting. Her specialties include medical nursing, palliative care and dementia care where she has worked in both management and project roles.
In 2014 Kathy was awarded the Hesta Australian Nursing Team Innovation award for the understanding Dementia program aimed at educating non clinical staff and volunteers about dementia and communicating with patients with dementia.
Kathy’s passion is working with older people and working with the community to promote living well.

Abstract:

An evaluation of the impact and success of the program was undertaken in July and September 2017. General feedback was collected by staff on a weekly basis and surveys were conducted with both clients and carers focusing on measuring satisfaction with the program, impact on behaviours of concern (in dementia clients), impact on overall client general health and the impact of the program on carer stress levels and overall carer health.

Biography:

Tessa is an Enrolled Nurse with 8 years experience working within the aged care sector providing care to residents and clients living with all stages of dementia. Tessa is passionate about aged care and has a particular focus on dementia care.

Tessa was instrumental in creating the program structure and implementation of the Treehouse ensuring all participants are meaningfully engaged in each session by providing personalised and flexible program options.

Tessa is commencing her Bachelor of Dementia Care in 2018 to continue to expand within her career. Tessa will be focusing on educating people about dementia and how to maintain positive relationships with people living with dementia and developing innovative services in regional areas

Abstract:

An evaluation of the impact and success of the program was undertaken in July and September 2017. General feedback was collected by staff on a weekly basis and surveys were conducted with both clients and carers focusing on measuring satisfaction with the program, impact on behaviours of concern (in dementia clients), impact on overall client general health and the impact of the program on carer stress levels and overall carer health.

Biography:

Centre for Ageing Studies University of Indonesia; Loughborough University

Abstract:

The number of people with dementia is growing worldwide. Early and accurate diagnosis is important. Growth will occur particularly in developing countries which often do not have the resources (staff, financial, equipment) to do an extensive dementia assessment. In this talk we will explore the different methods used to do a stepwise low cost and cross culturally applicable screening for dementia. Data from China, India, Indonesia, Australia the UK and Singapore are presented. We will show different methods including paper and pencil tasks and computerized assessments which have high validity and reliability./ These tests were originally developed at Oxford University and are now used as a gold standard in several settings

Biography:

A/Prof Reshma Merchant graduated from University of Edinburgh and currently a fellow of Royal College of Physician (Edin). She is currently the head of Division of Geriatric Medicine at the National University Hospital, Singapore. Her primary interest is in cognitive frailty.

Abstract:

Population health, and prevention of frailty and dementia has become a public health priority to reduce healthcare cost and institutionalisation. The primary aim of Healthy Ageing Promotion Program for You (HAPPY) was to improve cognition and function. Participants were older adults aged above 60 years recruited from senior activity centres and community. In addition to demographics data, information on frailty, quality of life, cognition and function was collected. Physical measurements including Short Performance Battery Test (SPPB)) was also carried out. Those screened to be pre-frail or frail and ambulant or have underlying cognitive impairment were invited to participate in HAPPY. Exclusion criteria included diagnosis of dementia and wheelchair bound.

40 participants were followed up for 3 months. Baseline characteristics of participants include mean age of 75.5 years. 25 (62.5%) of participants complained of subjective memory problems and 8 (20%) of participants had Mini Mental State Examination (MMSE) scores below 24. 29 (72.5%) had hypertension, 17 (42.5%) had hyperlipidaemia and 11 (27.5%) had diabetes. 8 (20%) of participants had 3 or more chronic diseases. 34 (85%) were prefrail and 5(12.5%) were classified as frail. After 3 months, MMSE mean scores improved from 25.9 to 26.8, and Montreal Cognitive Assessment mean scores improved from 23.0 to 24.9. In addition to cognitive scores, there was small but significant improvement in gait speed and total SPPB scores without any change in self rated quality of life. Community based engagement and intervention programs are useful in delaying the onset of dementia and frailty.