Current Research in Therapeutic Targets

Alzheimer's disease (AD) as of now exhibits one of the greatest medicinal services issues in the created nations. There is no successful treatment equipped for backing off infection movement. As of late the fundamental concentrate of research on novel pharmacotherapies depended on the amyloidogenic speculation of AD, which places that the beta amyloid (Aβ) peptide is primarily in charge of subjective hindrance and neuronal demise. The objective of such medicines is (a) to diminish Aβ creation through the restraint of β and γ secretase chemicals and (b) to advance disintegration of existing cerebral Aβ plaques. Be that as it may, this approach has turned out to be just unobtrusively viable. Late investigations propose an option methodology fixated on the restraint of the downstream Aβ flagging, especially at the neural connection. Aβ oligomers may cause deviant N-methyl-D-aspartate receptor (NMDAR) initiation postsynaptically by shaping buildings with the phone surface prion protein (PrPC). PrPC is enhanced at the neuronal postsynaptic thickness, where it collaborates with Fyn tyrosine kinase. Fyn enactment happens when Aβ is bound to PrPC-Fyn complex. Fyn causes tyrosine phosphorylation of the NR2B subunit of metabotropic glutamate receptor 5 (mGluR5). Fyn kinase blockers masitinib and saracatinib have ended up being effective in treating AD side effects in trial mouse models of the illness.

 

  • Amyloid Plaques
  • Loss of Neuronal Connections and Cell Death
  • Vascular Contributions to Alzheimer’s Disease

Related Conference of Current Research in Therapeutic Targets

November 13-14, 2024

31st Cognitive Neuroscience Congress

Dubai, UAE
November 18-19, 2024

33rd Euro Congress on Neurologists and Psychiatrists

Paris, France
November 25-26, 2024

19th Annual Congress on Neuroscience

Paris, France
November 26-27, 2024

4th Annual Dementia Congress

Paris, France
December 05-06, 2024

7th World Congress on Epilepsy and Brain Disorders

Dubai, UAE
December 05-06, 2024

9th Annual Congress on Pediatric Neurology and Pediatric Surgery

Prague, Czech Republic
December 11-12, 2024

9th World Congress on Spine and Spinal Disorders

Paris, France
December 12-13, 2024

36th World Congress on Neurorehabilitation

London, UK
December 12-13, 2024

38th European Neurology Congress

Rome, Italy
February 03-04, 2025

37th World Conference on Neurology

London, UK
February 17-18, 2025

5th International Conference on Child Neurology

Aix-en-Provence, France
February 20-21, 2025

6th International Conference on Neurologists

Amsterdam, Netherlands
February 24-25, 2025

6th Global Summit on Brain Disorders and Therapeutics

Madrid, Spain
February 24-25, 2025

4th International Conference onAlzheimer and Dementia

Madrid, Spain
February 27-28, 2025

7th World Depression Congress

Paris, France
March 10-11, 2025

8th World Conference on Neuroscience

Paris, France
March 13-14, 2025

7th World Conference on Neuroscience

Prague, Czech Republic
March 24-25, 2025

38th European Neurology Congress 2025

London, UK
April 24-25, 2025

6th World Congress on Sleep Disorders and Therapeutics

Amsterdam, Netherlands
April 29-30, 2025

11th International Conference on Epilepsy & Treatment

Barcelona, Spain
July 17-18, 2025

35th World Congress on Neurology and Neuroscience

Aix-en-Provence, France
July 23-24, 2025

15th Global Alzheimers Summit

Paris, France

Current Research in Therapeutic Targets Conference Speakers

    Recommended Sessions

    Related Journals

    Are you interested in